How did you go about investigating this question? And what can these investigations teach about the human brain?
NS: We focus our investigations on the elephant-nose fish, an animal that emits and detects electrical pulses to perceive and navigate its surroundings. In particular, we study a structure in the fish’s brain called the electrosensory lobe. This structure is very similar to the cerebellum, an ancient brain structure that is present in all vertebrates, including in people.
The electrosensory lobe helps the elephant-nose fish use its electrical pulses to detect nearby objects. For example, these pulses enable the fish to sense the minute electrical fields produced by the prey it wishes to eat. Remarkably, the fish can sense these small electrical fields even while the fish itself is producing much larger electric signals. We studied how this is done.
LA: These capabilities make this fish a powerful model for studying how circuits in the brain can cancel out self-generated sounds, or the effects of its own movement, thereby distinguishing between external and internal stimuli. In addition, this is a great system for exploring how brain circuits both process information and learn at the same time, and enable us to think about what happens when those circuits are disrupted.
What did you uncover about the cerebellum in your study?
NS: Previous work had shown that the fish’s electrosensory lobe, which is similar to the cerebellum, contains several layers of neurons stacked on top of each other. In this study, we discovered that neurons in the middle layer do something incredible.
LA: Most neurons generate bursts of electricity to communicate. But, importantly, these middle-layer neurons produce two different types of electrical bursts — one for learning and the other for communication.
SM: Earlier research had observed these dual signals but had not deciphered their role. We developed a mathematical model demonstrating that these signals actually emanate from different regions of the same neuron, and that this compartmentalized organization is what enables the circuit to learn on the go.
What impact could these findings have on medicine and technology?
NS: As we mentioned, the fish’s electrosensory lobe is remarkably similar to our own cerebellum. Recent evidence strongly suggests that our brains follow similar rules as those that allow fish to learn with flexibility and adaptability. Understanding those rules will help us to figure out how the brain grows and develops, as well as what goes wrong in disease when this circuitry gets disrupted. One example is tinnitus, or ringing in the ears. Tinnitus is a common and, in some cases, debilitating condition that is hypothesized to arise because of a malfunction of circuits in the human brain that normally function to cancel out self-generated sounds. Our work in the elephant-nose fish has the potential to inform efforts investigating the underlying mechanisms of this disorder.
LA: These findings could lead to machine-learning algorithms that more closely resemble what the brain does. At present, such algorithms divide learning and processing or communicating into two separate phases. The biological discovery we uncovered in our research suggests a new path forward: a learning mechanism that can do both things at once.
Your research brings together experimental neuroscience with theoretical neuroscience. Why are collaborations like these important?
NS: The brain is the most complex thing we know of. Building sophisticated mathematical models is absolutely essential for understanding how it works, because they give a roadmap for experimentalists like me to use as I continue to delve deeper into the mechanisms of learning.
LA: As a neuroscientist who was originally trained in physics, I obviously have a background different from Nate Sawtell’s, but rather than that getting in the way of our collaborations, we use our different approaches to great advantage. Building bridges between mathematics and biology makes for successful collaborations that drive science, medicine and technology forward.
SM: As a doctoral candidate here at Columbia’s Zuckerman Institute, I have been mentored by both Drs. Abbott and Sawtell, which has been incredibly rewarding. In neuroscience, you often take things apart to understand them. Our collaboration allows us to also put the pieces back together; our focus is not on solving a one piece of a problem, but on understanding a system with all of its pieces.
This paper is titled “Continual learning in a multi-layer network of an electric fish.” Additional contributors include Abigail Zadina. The research was supported by the National Institutes of Health (NS075023), the Irma T. Hirschl Trust, the Simons Foundation, the Gatsby Foundation and the National Science Foundation (1025849, NeuroNex Award DBI-1707398). The authors report no financial or other conflicts of interest.
Deeper reading: Continual Learning in a Multi-Layer Network of an Electric Fish
— Anne Holden, Zuckerman Institute